AYR opens Miami’s first medical cannabis dispensary

In 2025, AYR Wellness launched Miami-Midtown as its first dispensary located within Miami’s city limits, making news as the first legal medical cannabis store inside the municipal boundary. The company announced this as a milestone, signaling that the city of Miami itself (rather than just metro area) would now host AYR’s footprint. SITE: AYR WELLNESS

The press release noted it expands retail coverage in Florida, as AYR also opened new locations in Ohio concurrently. In a related “Retail Footprint Update” press release, AYR specifically referenced new locations in Miami, FL along with Niles, OH.

As of that expansion, AYR claimed 67 Florida retail locations on its network. The new Miami location helps fill a gap in core metro coverage.

First-month revenue: public numbers scarce

One challenge: I was unable to locate reliable, publicly reported figures for that dispensary’s first month revenue. AYR’s corporate disclosures for 2024 and 2025 report statewide performance, not by individual store. Their Q4 / full-year 2024 report shows $463.6 million in top-line revenue across all states. Their Q3 2024 report logged $114 million revenue and a $17 million operating loss across the enterprise.

But no breakdown for the Miami location is disclosed in press releases or local trade media. Thus any “first-month revenue” must remain speculative or internal.

Why AYR’s move in Miami is strategically relevant

1. City limits presence — urban visibility & legitimacy

While many dispensaries sat outside city limits or in suburbs, being physically in the city of Miami places AYR closer to population density, potential foot traffic, and brand recognition in core urban neighborhoods. It helps reduce the “far drive” objection from patients.

2. Reinforcing Florida dominance

AYR is already a major MSO (multi-state operator) in Florida via its acquisition of Liberty Health Sciences in 2021. That merger brought 31 Florida stores, cultivation assets, and existing market share. Over time, AYR has expanded further statewide — e.g., opening dispensaries in Jacksonville and Palm Beach Gardens in 2024.

By occupying Miami itself, they claim presence in one of the largest metro markets in Florida, giving them stronger retail coverage across southeast Florida.

3. Vertical integration & product control

AYR is a vertically integrated cannabis operator — meaning they control cultivation, processing, manufacturing, and retail. That integration helps with margin control, consistency, and supply chain resilience. Their Florida operations include constructing a large indoor cultivation facility (98,000 sq ft) expected to begin contributing revenue in 2025.

Thus, opening in Miami helps them funnel product from their internal supply to a high-demand retail node, reducing distribution friction and reinforcing brand consistency.

4. Market signal amid financial struggles

Notably, AYR is undergoing financial restructuring. In July 2025, press coverage noted that AYR plans to sell assets and wind down operations in various states, including Florida, via a restructuring. (turn0search21) The decision to open a dispensary in Miami during such a climate signals confidence (or necessity) to retain or expand market presence in its core state.

Thus, the Miami opening has symbolic weight: even with headwinds, AYR is investing in its home state.

What stands out & potential risks

Standouts

  • First in city limits: Miami-Midtown is claimed as the first dispensary within the city—a milestone for AYR’s brand and coverage.
  • Product breadth from day one: AYR’s dispensaries tend to launch with a full menu of forms (flower, vapes, edibles, concentrates) and house brands like Kynd and Origyn. Their Hollywood 2021 opening already featured flower, Origyn concentrates, and Big Pete’s Cookies.
  • Brand consistency: Patients expect consistent experience across stores; having a dispensary in Miami helps fulfill that expectation in a core metro.

Risks & open questions

  • High fixed costs & performance pressure: Whether Miami revenue will justify the expense depends on patient footfall, competition, and pricing.
  • Regulatory and municipal local rules: Even with state legalization of medical cannabis, municipal zoning, licensing, and local pushback can create constraints.
  • Financial health of parent company: With AYR restructuring, maintaining investment in new storefronts could be strained if capital dries up.
  • No disclosed first-month revenue: Without transparency on store performance, assessing ROI is speculative.

Presence

AYR Wellness’s Miami-Midtown dispensary holds symbolic and strategic importance. It is billed as Miami’s first city-limit medical cannabis location, giving AYR deeper urban penetration into one of Florida’s biggest markets. While we do not yet have reliable reporting on that location’s first-month revenue, the move helps reinforce AYR as a major Florida MSO with vertical integration and ambition.

In the context of AYR’s broader financial challenges and restructuring, the Miami opening serves as a signal: Florida remains central to their identity and future. Whether the dispensary meets demand expectations will be an early test of AYR’s ability to sustain growth under capital constraints.